Bisphosphonates in Medical Practice

Actions - Side Effects - Indications - Strategies

Author: Reiner Bartl,Bertha Frisch,Emmo Tresckow,Christoph Bartl

Publisher: Springer Science & Business Media

ISBN: 3540698701

Category: Medical

Page: 265

View: 3041

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Bones are everybody’s business. This means that clinical osteology, now an independent specialty, nevertheless encompasses all branches of medicine and affects each and every one of us. Intended for doctors who seek precise information on bisphosphonates in medical practice, this book has been designed as an up-to-date manual to deal with the currently recognized indications for bisphosphonates, to outline situations and conditions for prevention of skeletal disorders, and to provide practical guidelines for treatment.

Medication-Related Osteonecrosis of the Jaws

Bisphosphonates, Denosumab, and New Agents

Author: Sven Otto

Publisher: Springer

ISBN: 3662437333

Category: Medical

Page: 220

View: 8163

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Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.


Osteoporosis in Clinical Practice

A Practical Guide for Diagnosis and Treatment

Author: Piet Geusens

Publisher: Springer Science & Business Media

ISBN: 144713382X

Category: Medical

Page: 188

View: 1389

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A concise review of the current knowledge of osteoporosis, aimed at the busy pratitioner who is increasingly involved in the management of osteoporosis and who wants accurate and practical answers to questions that arise in daily clinical practice. All the major aspects are covered including diagnosis, fractures, prevention and treatment. Each chapter has been written by a recognised expert in the field to provide readers with the most up-to-date and authoritative knowledge on each of the topics discussed, making this an invaluable source of reference.

Issues in Clinical Medicine Research and Practice: 2011 Edition

Author: N.A

Publisher: ScholarlyEditions

ISBN: 146496484X

Category: Medical

Page: 1210

View: 886

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Issues in Clinical Medicine Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Clinical Medicine Research and Practice. The editors have built Issues in Clinical Medicine Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Clinical Medicine Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Clinical Medicine Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach

Author: Francesco Saverio De Ponte

Publisher: Springer Science & Business Media

ISBN: 9788847020832

Category: Medical

Page: 181

View: 8422

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During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.

Prevention of Bone Metastases

Author: Markus Joerger,Michael Gnant

Publisher: Springer Science & Business Media

ISBN: 3642218911

Category: Medical

Page: 233

View: 6987

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Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in not only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. One important focus of the book is the efficacy of bisphosphonates in preventing bone metastases in patients with breast, lung, and prostate cancer and disease progression in cases of multiple myeloma. The combined use of bisphosphonates and cytostatics is also discussed, with a report on first clinical data. Further topics addressed include the significance of the bone microenvironment, special issues in the elderly patient, the use of bone turnover markers, and initial findings obtained with denosumab.

Harty's Endodontics in Clinical Practice E-Book

Author: Bun San Chong

Publisher: Elsevier Health Sciences

ISBN: 0702065129

Category: Medical

Page: 304

View: 952

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This book is a guide to proven, current clinical endodontic practice. It is designed, primarily, with the undergraduate readership in mind but is also suitable for anyone pursuing specialist training, including extended skills in endodontics, and general dental practitioners undertaking CPD, or wishing to keep up-to-date. The seventh edition is available with an online question bank containing MCQs and Clinical Cases. Practical approach to the subject, taking the reader through every step of endodontic practice from its scientific basis to patient assessment and through to clinical techniques Helpful pedagogic features – including Learning Outcomes and Summary Boxes – help reinforce learning International experts and contributors help ensure good coverage and currency of information Explores areas of debate when they exist to reflect differing approaches to treatment intervention Explains the potential impact of systemic conditions and disorders, as well as medications, on endodontic treatment planning and management Discusses the diagnosis of orofacial pain and the appropriate use of antibiotics and analgesics Explores the maintenance of pulp vitality and the prevention of apical periodontitis in the context of operative dentistry Provides an overview of instruments and devices used during endodontic treatment Describes the fundamental principles of canal filling using gutta-percha, as well as the use of alternative materials, and newer root filling techniques Discusses the management of dental trauma with emphasis on accurate diagnosis, timely and appropriate treatment, and follow-up Explores the interface between endodontic-periodontal disease in the context of diagnosis, treatment and prognostic assessment Discusses common challenges such as inadequate pain control and problems with preparation and filling of the root canal system Written at a level which is ideal for dental students, general dental practitioners and those pursuing specialist training or seeking to keep up-to-date Comes with access to an online question bank containing a wide range of MCQs and Clinical Cases to help reinforce learning! Richly illustrated with over 80 colour artworks – many created by the Gray’s Anatomy illustration team – and 350 photographs, many of which are previously unpublished Explores advances in our understanding of the role of microorganisms in the pathogenesis of pulpal and periradicular diseases and the role of host defence response against root canal infection Explores the use of newer imaging techniques such as three-dimensional tomography in determining pulp space anatomy and in treatment planning Explains recent advances in material technology, molecular biology and regenerative medicine in the management of deep caries and maintenance of pulp vitality Explores the effective use of existing and newer chemomechanical preparation techniques and intracanal medication for thorough root canal system decontamination Explores advances in the techniques available for restoring endodontically treated teeth

Oral and Maxillofacial Surgery: Trauma, surgical pathology, temporomandibular disorders

Author: Robert D. Marciani

Publisher: Saunders

ISBN: N.A

Category: Medical

Page: 1004

View: 7002

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In three volumes, this resource provides in-depth information to help you perfect your oral and maxillofacial surgical technique and provide state-of-the-art care for your patients. The full scope of the field is represented with up-to-date, evidence-based coverage of every surgical procedure performed today, including orthognathic surgery, trauma surgery, surgical pathology, surgery of TM disorders, placement of dental implants, cleft palate correction, dentoalveolar surgery, craniofacial surgery, cosmetic surgery, and reconstructive surgery. More than 2,600 high-quality images and illustrations, plus 32-page color inserts in each volume, serve as valuable visual references. Youll also find complete guidelines for a wide range of practice issues such as anesthesia, diagnostic imaging, treatment planning, rehabilitation and physical therapy, psychological considerations, and office design and ergonomics. A new team of volume and section editors offers a fresh perspective on oral and maxillofacial surgery, bringing their experience and expertise to the topics featured in this edition. Over 100 new, highly-detailed illustrations created by a leading medical illustrator help you quickly visualize and retain new concepts and techniques. Case reports throughout the book enable you to follow the treatment progress of patients with a variety of disorders and conditions, from preoperative to postoperative.

Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464963401

Category: Medical

Page: 4090

View: 4250

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Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pediatric and Adolescent Medicine Research and Practice. The editors have built Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pediatric and Adolescent Medicine Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in National, Regional, and Environmental Health and Medicine: 2011 Edition

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464964602

Category: Medical

Page: 1345

View: 5081

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Issues in National, Regional, and Environmental Health and Medicine: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about National, Regional, and Environmental Health and Medicine. The editors have built Issues in National, Regional, and Environmental Health and Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about National, Regional, and Environmental Health and Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in National, Regional, and Environmental Health and Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Hypercalcemia of Malignancy

Author: Friedhelm Raue

Publisher: Springer Science & Business Media

ISBN: 3642850731

Category: Medical

Page: 163

View: 6072

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Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.

Glucocorticoid-induced Osteoporosis

Author: Andrea Giustina,Alberto Angeli,Ernesto Canalis

Publisher: Karger Medical and Scientific Publishers

ISBN: 3805572964

Category: Medical

Page: 204

View: 9070

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Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.


Issues in Family Medicine Research and Practice: 2011 Edition

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464965382

Category: Medical

Page: 932

View: 8440

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Issues in Family Medicine Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Family Medicine Research and Practice. The editors have built Issues in Family Medicine Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Family Medicine Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Family Medicine Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Bisphosphonates in Bone Disease

From the Laboratory to the Patient

Author: Herbert Fleisch

Publisher: Elsevier

ISBN: 0080573908

Category: Medical

Page: 212

View: 8312

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This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, Fourth Edition, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs. The revised fourth edition contains approximately 50% new material Includes information on all the latest drugs

Nutrition in Pediatrics

Basic Science, Clinical Applications

Author: Christopher Duggan,John B. Watkins,W. Allan Walker

Publisher: PMPH-USA

ISBN: 9781550093612

Category: Health & Fitness

Page: 923

View: 9688

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The field of paediatric nutrition has developed into an area essential to components of academic paediatric program throughout the world. Among the paediatric texts available, none deals with the physiologic or pathophysiologic basis of nutrition in paediatric health and disease in children of all ages. Extending physiologic and pathophysiologic considerations to their coverage of nutritional needs with respect to disease and covers diagnosis of nutritional imbalance and management as well.The 4th edition includes an entirely new section on paediatric obesity: epidemiology, pathophysiology, assessment and treatment. It includes new chapters on celiac disease, food allergies and iron. This edition includes updated growth curves, including the newly released WHO growth curves for exclusively breastfed infants. Sections include basic concepts in the development of nutritional requirements of infants and children and a pathophysiology section examining cardinal manifestations and development. These sections will augment a comprehensive approach to perinatal nutrition, nutrition of specific disease states and nutritional management.


Netter Collection of Medical Illustrations: Endocrine System E-book

Author: William F. Young

Publisher: Elsevier Health Sciences

ISBN: 1437736475

Category: Medical

Page: 256

View: 9220

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Endocrine System, 2nd Edition provides a concise and highly visual guide to the anatomy, physiology, and pathophysiology of the endocrine glands. This volume in The Netter Collection of Medical Illustrations (the CIBA "Green Books") has been expanded and revised by Dr. William F. Young, Jr. to reflect the many exciting advances that have been made in the field. Classic Netter art, updated illustrations, and modern imaging make this timeless work essential to your library. Access rare illustrations in one convenient source from the only Netter work devoted specifically to the endocrine system. Get a complete overview of the endocrine system through multidisciplinary coverage of endocrinology as a whole. Gain a quick understanding of complex topics from a concise text-atlas format that provides a context bridge between primary and specialized medicine. Apply a visual approach—with the classic Netter art, updated illustrations, new artwork and modern imaging—to normal and abnormal endocrine gland function and the clinical presentation patients with endocrine disorders. Clearly see the connection between basic and clinical sciences with an integrated overview of normal structure and function as it relates to pathologic conditions. Delve into updated text of new author and editor, William F. Young, Jr., MD., that illuminates and expands on the illustrated concepts. Benefit from the perspectives of an international advisory board for content that reflects the current global consensus.

Dento-Alveolar Complications, An Issue of Oral and Maxillofacial Surgery Clinics - E-Book

Author: Dennis-Duke R. Yamashita,James P. McAndrews

Publisher: Elsevier Health Sciences

ISBN: 1455712124

Category: Medical

Page: 136

View: 7394

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A comprehensive review of dento-alveolar complications for the oral and maxillofacial surgeon! Topics will include bleeding, dento-alveolar infections, infections extending into the neck, osteomyelitis and osteitis, endodontic complications, nerve injuries, local anesthesia, pathology, bone grafting, osteoradionecrosis, bisphosphonate associated jaw necrosis, and much more!