Classics in Total Synthesis

Targets, Strategies, Methods

Author: K. C. Nicolaou,E. J. Sorensen

Publisher: Wiley-VCH

ISBN: 9783527292844

Category: Science

Page: 821

View: 4370

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This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

Classics in Total Synthesis III

Further Targets, Strategies, Methods

Author: K. C. Nicolaou,Jason S. Chen

Publisher: John Wiley & Sons

ISBN: 3527329579

Category: Science

Page: 746

View: 4868

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A wonderful tool for learning and teaching, and a must-have for all current and future organic, medicinal and biological chemists. --Book Jacket.

Classics in Total Synthesis II

More Targets, Strategies, Methods

Author: K. C. Nicolaou

Publisher: Wiley-VCH

ISBN: 9783527306848

Category: Science

Page: 639

View: 6278

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Classics in Total Synthesis II is the long awaited sequel to Classics in Total Synthesis, a book that has made its mark as a superb tool for educating students and practitioners alike in the art of organic synthesis since its introduction in 1996. In this highly welcomed second volume, K.C. Nicolaou and Scott A. Snyder discuss in detail the most impressive accomplishments in natural product total synthesis during the 1990s and the first years of the 21st century. While all of the features that made the first volume of Classics so popular and unique as a teaching tool have been maintained, in this new treatise the authors seek to present the latest techniques and advance in organic synthesis as they beautifully describe the works of some of the most renowned synthetic organic chemists of our time. Key features include: Systematically develops domino reactions, cascade sequences, biomimetic strategies, and asymmetric catalysis through the chosen synthesis Discusses cutting edge synthetic technologies in terms of mechanism and scope Presents new reactions, such as olefin metathesis, in mini-review style Includes abundant references for further reading CD with useful teaching material for lecturers is included with hardback version (ISBN 3-527-30685-4) Graduate students, educators, and researchers in the fields of synthetic and medicinal chemistry will wish to have a copy of this book in their collection as an indispensable companion that both augments and supplements the original Classics in Total Synthesis. From the reviews: "... a volume, (...) which any chemist with an interest in synthetic organic chemistry will wish to acquire." –JACS (on the previous volume) "...this superb book (...) will be an essential purchase for many organic chemists." –Nature (on the previous volume) "...Classics II is undoubtedly an excellent bargain that is highly recommended to everybody interested in advanced organic chemistry. One of my co-workers confessed that Classics I was the book on his bedside table while he prepared his thesis defense. Isn't that the highest distinction for a monograph? I have every reason to believe that Classics II will equally stand the selection process by students (and probably their supervisors too)." –Angewandte Chemie, 2004 "Well, there is a new pleasant read for the advanced student and even the experienced. It is the second volume to the established Classics in Total Synthesis and it continues the series extremely well." –ChemBioChem, 2004 "...the real innovation of this volume is the inclusion of alternative pathways to the same target molecule by other researchers. This enables the reader to appreciate that there are also other solutions to certain structural problems than those of the original synthesis. ... Let us hope that K. C. Nicolaou and his associates will present us with these future achievements in the same clear, informative and innovative format they have with the previous two volumes." –Applied Organometallic Chemistry

Biomimetic Organic Synthesis

Author: Erwan Poupon,Bastien Nay

Publisher: John Wiley & Sons

ISBN: 3527634762

Category: Science

Page: 1024

View: 6107

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In this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of complex natural products is laid out, backed by abundant practical examples from the authors' own work as well as from the published literature. Volume 1 describes the biomimetic synthesis of alkaloids. Volume 2 covers terpenes, polyketides, and polyphenols. A discussion of the current challenges and frontiers in biomimetic synthesis concludes this comprehensive handbook. Key features: Biomimetic Strategies have become an every-day tool not only for chemists but also for biologists. The synthetic applications are overwhelming, making this comprehensive 2 volume work a must-have for everyone working in the field. Unifying both synthetic and biosynthetic aspects, this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry.

Efficiency in Natural Product Total Synthesis

Author: Pei-Qiang Huang,Zhu-Jun Yao,Richard P. Hsung

Publisher: John Wiley & Sons

ISBN: 1118940210

Category: Science

Page: 512

View: 8402

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Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals

Natural Products in Medicinal Chemistry

Author: Stephen Hanessian

Publisher: John Wiley & Sons

ISBN: 3527676562

Category: Medical

Page: 652

View: 8793

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The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Green Techniques for Organic Synthesis and Medicinal Chemistry

Author: Wei Zhang,Berkeley Cue

Publisher: John Wiley & Sons

ISBN: 0470711515

Category: Medical

Page: 742

View: 6444

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Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts: Introduction: Introduces the reader to the toxicology of organic chemicals,their environmental impact, and the concept of green chemistry. Green Catalysis: Covers a variety of green catalytic techniques including organocatalysis, supported catalysis, biocatalysis, fluorous catalysis, and catalytic direct C-H bond activation reactions. Green Synthetic Techniques: Presents a series of new techniques, assessing the green chemistry aspects and limitations (i.e. cost, equipment, expertise). Techniques include reactions in alternative solvents, atom economic multicomponent reactions, microwave and ultrasonic reactions, solid-supported synthesis, fluorous and ionic liquid-based recycling techniques, and flow reactors. Green Techniques in Pharmaceutical Industry: Covers applications of green chemistry concepts and special techniques for medicinal chemistry, including synthesis, analysis, separation, formulation, , and drug delivery. Process and business case studies are included to illustrate the applications in the pharmaceutical industry. Green Techniques for Organic Synthesis and Medicinal Chemistry is an essential resource on green chemistry technologies for academic researchers, R&D professionals and students working in organic chemistry and medicinal chemistry.

Asymmetric Organocatalysis in Natural Product Syntheses

Author: Mario Waser

Publisher: Springer Science & Business Media

ISBN: 3709111633

Category: Science

Page: 197

View: 8769

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This book provides the reader with an illustrative overview concerning successful and widely used applications of organocatalysis in the field of natural product synthesis. The main focus will be on organocatalytic key-steps for each (multi-step) synthesis described, whereas other often particularly innovative transformations will be omitted, as this would be beyond the scope of this volume.

Der stumme Frühling

Author: Rachel Carson

Publisher: C.H.Beck

ISBN: 3406704220

Category: Nature

Page: 348

View: 5364

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Der stumme Frühling erschien erstmals 1962. Der Titel bezieht sich auf das eingangs erzählte Märchen von der blühenden Stadt, in der sich eine seltsame, schleichende Seuche ausbreitet … Das spannend geschriebene Sachbuch wirkte bei seinem Erscheinen wie ein Alarmsignal und avancierte rasch zur Bibel der damals entstehendenÖkologie-Bewegung. ZumerstenMal wurde hier in eindringlichem Appell die Fragwürdigkeit des chemischen Pflanzenschutzes dargelegt. An einer Fülle von Tatsachen machte Rachel Carson seine schädlichen Auswirkungen auf die Natur und die Menschen deutlich. Ihre Warnungen haben seither nichts von ihrer Aktualität verloren.

The Design of Everyday Things

Psychologie und Design der alltäglichen Dinge

Author: Norman Don

Publisher: Vahlen

ISBN: 3800648105

Category: Business & Economics

Page: 320

View: 7028

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Apple, Audi, Braun oder Samsung machen es vor: Gutes Design ist heute eine kritische Voraussetzung für erfolgreiche Produkte. Dieser Klassiker beschreibt die fundamentalen Prinzipien, um Dinge des täglichen Gebrauchs umzuwandeln in unterhaltsame und zufriedenstellende Produkte. Don Norman fordert ein Zusammenspiel von Mensch und Technologie mit dem Ziel, dass Designer und Produktentwickler die Bedürfnisse, Fähigkeiten und Handlungsweisen der Nutzer in den Vordergrund stellen und Designs an diesen angepasst werden. The Design of Everyday Things ist eine informative und spannende Einführung für Designer, Marketer, Produktentwickler und für alle an gutem Design interessierten Menschen. Zum Autor Don Norman ist emeritierter Professor für Kognitionswissenschaften. Er lehrte an der University of California in San Diego und der Northwest University in Illinois. Mitte der Neunzigerjahre leitete Don Norman die Advanced Technology Group bei Apple. Dort prägte er den Begriff der User Experience, um über die reine Benutzbarkeit hinaus eine ganzheitliche Erfahrung der Anwender im Umgang mit Technik in den Vordergrund zu stellen. Norman ist Mitbegründer der Beratungsfirma Nielsen Norman Group und hat unter anderem Autohersteller von BMW bis Toyota beraten. „Keiner kommt an Don Norman vorbei, wenn es um Fragen zu einem Design geht, das sich am Menschen orientiert.“ Brand Eins 7/2013 „Design ist einer der wichtigsten Wettbewerbsvorteile. Dieses Buch macht Spaß zu lesen und ist von größter Bedeutung.” Tom Peters, Co-Autor von „Auf der Suche nach Spitzenleistungen“


Organische Chemie II für Dummies

Author: John T. Moore,Richard Langley

Publisher: John Wiley & Sons

ISBN: 3527707204

Category: Chemistry, Organic

Page: 360

View: 6421

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Die Organische Chemie, die Welt des Kohlenstoffs, ist spannend, vielschichtig und manchmal auch ein wenig schwer zu verstehen. Dieses Buch ist das richtige für Sie, wenn Sie etwas mehr als nur die Grundlagen der Organik verstehen müssen und etwas tiefer in die Materie eindringen wollen. Sie erfahren, was Sie über Alkohole, Ether und Spektroskopie wissen sollten, was aromatische Verbindungen ausmacht, was es mit Carbonylen auf sich hat und vieles mehr. Auch kniffelige Themen wie Organometalle, Amine und Biomoleküle kommen nicht zu kurz. So bietet John T. Moore in diesem Buch einen leicht verständlichen Überblick über die etwas fortgeschrittenere Organische Chemie.

Reactive Intermediates in Organic Chemistry

Structure, Mechanism, and Reactions

Author: Maya Shankar Singh

Publisher: John Wiley & Sons

ISBN: 3527678271

Category: Science

Page: 296

View: 9798

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Most reactions in organic chemistry do not proceed in a single step but rather take several steps to yield the desired product. In the course of these multi-step reaction sequences, short-lived intermediates can be generated that quickly convert into other intermediates, reactants, products or side products. As these intermediates are highly reactive, they cannot usually be isolated, but their existence and structure can be proved by theoretical and experimental methods. Using the information obtained, researchers can better understand the underlying reaction mechanism of a certain organic transformation and thus develop novel strategies for efficient organic synthesis. The chapters are clearly structured and are arranged according to the type of intermediate, providing information on the formation, characterization, stereochemistry, stability, and reactivity of the intermediates. Additionally, representative examples and a problem section with different levels of difficulty are included for self-testing the newly acquired knowledge. By providing a deeper understanding of the underlying concepts, this is a musthave reference for PhD and Master Students in organic chemistry, as well as a valuable source of information for chemists in academia and industry working in the field. It is also ideal as primary or supplementary reading for courses on organic chemistry, physical organic chemistry or analytical chemistry.

Strategies and Tactics in Organic Synthesis

Author: Michael Harmata

Publisher: Academic Press

ISBN: 9780124502833

Category: Science

Page: 415

View: 8149

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This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way. It provides a window into the world of design, function and synthesis that is at the leading edge of the molecular frontier.


Physikalische Chemie

Author: Peter W. Atkins,Julio de Paula,Michael Bär,Anna Schleitzer,Carsten Heinisch

Publisher: John Wiley & Sons

ISBN: 3527315462

Category: Science

Page: 1220

View: 9437

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Grounded theory

Strategien qualitativer Forschung

Author: Barney G. Glaser,Anselm L. Strauss,Axel T. Paul

Publisher: N.A

ISBN: 9783456849065

Category:

Page: 278

View: 400

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Der Klassiker über den qualitativen Forschungsansatz der "Grounded Theory", geschrieben von den Entwicklern dieser Methode "Obwohl unser Buch sich in erster Linie an Soziologen richtet, glauben wir, dass es jedem nutzen kann, der daran interessiert ist, soziale Phänomene zu untersuchen politischer, pädagogischer, wirtschaftlicher, industrieller oder welcher Art auch immer." In der Tat ist "Grounded Theory" quer durch die wissenschaftlichen Disziplinen zum Standardbegriff der qualitativen Sozialforschung ge - worden. Die inzwischen zum Klassiker avancierte Arbeit von Glaser und Strauss eröffnet eine lehrbare und auch lernbare Forschungsstrategie. Das Konzept bietet eine Antwort auf das Problem, die oft schmerzlich empfundene Lücke zwischen empirischer Forschung und Theorie zu schliessen.

The Way of Synthesis

Evolution of Design and Methods for Natural Products

Author: Tomas Hudlicky,Josephine W. Reed

Publisher: Wiley-VCH

ISBN: N.A

Category: Science

Page: 1032

View: 8962

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This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. "I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication." (Victor Snieckus)