Genetics

Genes, Genomes, and Evolution

Author: Philip Meneely,Rachel Dawes Hoang,Katherine Heston,Iruka N. Okeke

Publisher: Oxford University Press

ISBN: 019879536X

Category: Science

Page: 740

View: 8974

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Recent advances that allow scientists to quickly and accurately sequence a genome have revolutionized our view of the structure and function of genes as well as our understanding of evolution. A new era of genetics is underway, one that allows us to fully embrace Dobzhansky's famous statement that "Nothing in biology makes sense except in the light of evolution". Genetics: Genes, Genomes, and Evolution presents the fundamental principles of genetics and molecular biology from an evolutionary perspective as informed by genome analysis. By using what has been learned from the analyses of bacterial and eukaryotic genomes as its basis, the book unites evolution, genomics, and genetics in one narrative approach. Genomic analysis is inherently both molecular and evolutionary, and every chapter is approached from this unified perspective. Similarly, genomic studies have provided a deeper appreciation of the profound relationships between all organisms - something reflected in the book's integrated discussion of bacterial and eukaryotic evolution, genetics and genomics. It is an approach that provides students with a uniquely flexible and contemporary view of genetics, genomics, and evolution. Online Resource Centre: - Video tutorials: a series of videos that provide deeper, step-by-step explanations of a range of topics featured in the text. - Flashcards: electronic flashcards covering the key terms from the text. For registered adopters of the text: - Digital image library: Includes electronic files in PowerPoint format of every illustration, photo, graph and table from the text - Lecture notes: Editable lecture notes in PowerPoint format for each chapter help make preparing lectures faster and easier than ever. Each chapter's presentation includes a succinct outline of key concepts, and incorporates the graphics from the chapter - Library of exam-style questions: a suite of questions from which you can pick potential assignments and exams. - Test bank of multiple-choice questions: a ready-made electronic testing resource that can be customized by lecturers and delivered via their institution's virtual learning environment. - Solutions to all questions featured in the book: solutions written by the authors help make the grading of homework assignments easier. - Journal Clubs: a series of questions that guide your students through the reading and interpretation of a research paper that relates to the subject matter of a given chapter. Each Journal club includes model answers for lecturers. - Instructor's guide: The instructor's guide discusses the educational approach taken by Genetics: Genes, Genomes, and Evolution in more detail, why this approach has been taken, what benefits it offers, and how it can be adopted in your class.

Genetics

Genes, Genomes, and Evolution

Author: Philip Meneely,Rachel Dawes Hoang,Iruka N. Okeke,Katherine Heston

Publisher: N.A

ISBN: 9780198712558

Category:

Page: 776

View: 8461

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Recent advances that allow scientists to quickly and accurately sequence a genome have revolutionized our view of the structure and function of genes as well as our understanding of evolution. A new era of genetics is underway, one that allows us to fully embrace Dobzhansky's famous statementthat "Nothing in biology makes sense except in the light of evolution". Genetics: Genes, Genomes, and Evolution presents the fundamental principles of genetics and molecular biology from an evolutionary perspective as informed by genome analysis.By using what has been learned from the analyses of bacterial and eukaryotic genomes as its basis, the book unites evolution, genomics, and genetics in one narrative approach. Genomic analysis is inherently both molecular and evolutionary, and every chapter is approached from this unifiedperspective. Similarly, genomic studies have provided a deeper appreciation of the profound relationships between all organisms - something reflected in the book's integrated discussion of bacterial and eukaryotic evolution, genetics and genomics. It is an approach that provides students with a uniquely flexibleand contemporary view of genetics, genomics, and evolution. Online Resource Centre:* Video tutorials: a series of videos that provide deeper, step-by-step explanations of a range of topics featured in the text.* Flashcards: electronic flashcards covering the key terms from the text. For registered adopters of the text:* Digital image library: Includes electronic files in PowerPoint format of every illustration, photo, graph and table from the text* Lecture notes: Editable lecture notes in PowerPoint format for each chapter help make preparing lectures faster and easier than ever. Each chapter's presentation includes a succinct outline of key concepts, and incorporates the graphics from the chapter* Library of exam-style questions: a suite of questions from which you can pick potential assignments and exams.* Test bank of multiple-choice questions: a ready-made electronic testing resource that can be customized by lecturers and delivered via their institution's virtual learning environment.* Solutions to all questions featured in the book: solutions written by the authors help make the grading of homework assignments easier.* Journal Clubs: a series of questions that guide your students through the reading and interpretation of a research paper that relates to the subject matter of a given chapter. Each Journal club includes model answers for lecturers.* Instructor's guide: The instructor's guide discusses the educational approach taken by Genetics: Genes, Genomes, and Evolution in more detail, why this approach has been taken, what benefits it offers, and how it can be adopted in your class.

Genetic Analysis

Genes, Genomes, and Networks in Eukaryotes

Author: Philip Meneely

Publisher: Oxford University Press

ISBN: 0199681260

Category: Medical

Page: 552

View: 3766

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With its unique integration of genetics and molecular biology, this text probes fascinating questions that explore how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, andepigenetics, the book goes on to explore the use of gene mutations, the analysis of gene expression and activity, a discussion of the genetic structure of natural populations, and more.

Adaptive Evolution of Genes and Genomes

Author: Austin L. Hughes

Publisher: Oxford University Press, USA

ISBN: 9780195116267

Category: Science

Page: 270

View: 6656

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This valuable book thoroughly examines adaptive evolution at the DNA level while taking a comprehensive look at the research being done in the area. It presents useful cases where signals of adaptive evolution are detected through neutral molecular evolution, providing a powerful strategy for testing the Darwinian hypothesis of natural selection. By bridging the gap between research on molecular and phenotype evolution and contributing to the unification of the biological sciences, this book will especially appeal to researchers and graduate students in the field of evolutionary biology. Also, with its focus on particular protein molecules and on specific domains of these proteins, it will benefit a wider audience of both evolutionary and functional biologists.

Plant Genes, Genomes and Genetics

Author: Erich Grotewold,Elizabeth Kellogg,Joseph Chappell

Publisher: John Wiley & Sons

ISBN: 1119998875

Category: Science

Page: 264

View: 1751

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Plant Genes, Genomes and Genetics provides a dedicated, plant focused textbook for graduates and advanced undergraduates. The book considers the control of plant gene expression in the broad sense from the mechanism of transcription to the generation of a protein and will provide a general idea of how these processes occur in plants, specifically highlighting cases when plants and other organisms are different. Plant gene expression continues to be taught from general textbooks that focus primarily on yeast and animals for eukaryotes, yet rarely mention plants so this book aims to fill that gap in teaching material. This book will be the first book in the Wiley-Blackwell/ASPB Plant Biology Book Series.

The Origins of Genome Architecture

Author: Michael Lynch

Publisher: Sinauer Associates Incorporated

ISBN: N.A

Category: Medical

Page: 494

View: 8738

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The availability of genomic blueprints for hundreds of species has led to a transformation in biology, encouraging the proliferation of adaptive arguments for the evolution of genomic features, yet often sacrificing simpler, more compelling explanations. This textbook explains why the details matter and presents an explanatory framework for how the architectural diversity of eukarotic genomes and genes came to arise. Presented in non-technical fashion, it is compatible for use in an advanced Genetics course and as a professional reference.

Bioinformatics for Beginners

Genes, Genomes, Molecular Evolution, Databases and Analytical Tools

Author: Supratim Choudhuri

Publisher: Elsevier

ISBN: 0124105106

Category: Medical

Page: 238

View: 1795

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Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses the relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis and demonstrates, with examples, targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis, also pointing to further study options. Avoids non-essential coverage, yet fully describes the field for beginners Explains the molecular basis of evolution to place bioinformatic analysis in biological context Provides useful links to the vast resource of publicly available bioinformatic databases and analysis tools Contains over 100 figures that aid in concept discovery and illustration

The Future of Genetics

Beyond the Human Genome Project

Author: Russ Hodge

Publisher: Infobase Publishing

ISBN: 0816066841

Category: Juvenile Nonfiction

Page: 204

View: 1338

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Presents an overview of current innovations in genetic research and considers their impact on science and medicine, including the causes of aging and death, the brain, and quality of life.

Genome

The Autobiography of a Species in 23 Chapters

Author: Matt Ridley

Publisher: Harper Collins

ISBN: 0062253468

Category: Science

Page: 368

View: 7782

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The genome's been mapped. But what does it mean? Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

Mitochondrial Genome Evolution

Author: N.A

Publisher: Academic Press

ISBN: 0123944422

Category: Science

Page: 488

View: 4556

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Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on Mitochondrial genome evolution. Publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology This thematic volume features reviews on mitochondrial genome evolution

Genetics

From Genes to Genomes

Author: Leland Hartwell

Publisher: McGraw-Hill Companies

ISBN: 9780075409236

Category: Science

Page: 813

View: 3511

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"Genetics: From Genes to Genomes" is a cutting-edge, introductory genetics text authored by an unparalleled author team, including Nobel Prize winner, Leland Hartwell. The Third Edition continues to build upon the integration of Mendelian and molecular principles, providing students with the links between early genetics understanding and the new molecular discoveries that have changed the way the field of genetics is viewed.

Evolution, Development, & the Predictable Genome

Author: David Lawrence Stern

Publisher: Roberts & Company

ISBN: N.A

Category: Science

Page: 264

View: 4350

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For too long, efforts to synthesize evolution and development have failed to build a united view of the origins and evolution of biological diversity. In this groundbreaking book, David Stern sets out to draw evolutionary biology and developmental biology together by cutting through the differences that divide the disciplines and by revealing their deeper similarities. He draws upon the insights of generations of evolutionary biologists and scores of developmental biologists to build a solid foundation for future investigation of the genetic and developmental causes of diversity. Along the way, and in plain English, he explicates many of the guiding principles of evolution, population genetics, and developmental biology. Each chapter offers a clear review of fundamental principles, together with thoughtprovoking ideas that will be tested only with data emerging from current and future studies. With the basic principles established, he then offers a new way of thinking about development--backwards--to clarify precisely how the mechanisms of development influence evolution. In the same spirit, he takes a fresh look at evolution in populations, arguing that population history influences precisely how developmental mechanisms evolve. Both Stern's new perspective on development and his reassessment of the role of populations leads to the surprising conclusion that the evolution of genomes appears to be predictable. Stern argues that developmental biology and evolutionary biology are intertwined: it is impossible to understand one of them fully without understanding the other. This book provides a clear and wide-ranging introduction to evolution and development for the basic reader; graduate students will be introduced to the cutting-edge of research in evolutionary developmental biology; and experts in evolution or development will receive both an uncomplicated introduction to the other discipline and an abundance of new, provocative ideas.

Polyploidy and Genome Evolution

Author: Pamela Soltis,Douglas E. Soltis

Publisher: Springer Science & Business Media

ISBN: 3642314414

Category: Science

Page: 420

View: 8347

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Polyploidy – whole-genome duplication (WGD) – is a fundamental driver of biodiversity with significant consequences for genome structure, organization, and evolution. Once considered a speciation process common only in plants, polyploidy is now recognized to have played a major role in the structure, gene content, and evolution of most eukaryotic genomes. In fact, the diversity of eukaryotes seems closely tied to multiple WGDs. Polyploidy generates new genomic interactions – initially resulting in “genomic and transcriptomic shock” – that must be resolved in a new polyploid lineage. This process essentially acts as a “reset” button, resulting in genomic changes that may ultimately promote adaptive speciation. This book brings together for the first time the conceptual and theoretical underpinnings of polyploid genome evolution with syntheses of the patterns and processes of genome evolution in diverse polyploid groups. Because polyploidy is most common and best studied in plants, the book emphasizes plant models, but recent studies of vertebrates and fungi are providing fresh perspectives on factors that allow polyploid speciation and shape polyploid genomes. The emerging paradigm is that polyploidy – through alterations in genome structure and gene regulation – generates genetic and phenotypic novelty that manifests itself at the chromosomal, physiological, and organismal levels, with long-term ecological and evolutionary consequences.

Molecular and Genome Evolution

Author: Dan Graur

Publisher: N.A

ISBN: 9781605354699

Category: Evolution (Biology)

Page: 500

View: 1861

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This title describes the driving forces behind the evolutionary process at the molecular and genome levels, the effects of the various molecular mechanisms on the structure of genes, proteins, and genomes.

Adam and the Genome

Reading Scripture after Genetic Science

Author: Scot McKnight,Dennis R. Venema

Publisher: Brazos Press

ISBN: 1493406744

Category: Religion

Page: 240

View: 9054

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Genomic science indicates that humans descend not from an individual pair but from a large population. What does this mean for the basic claim of many Christians: that humans descend from Adam and Eve? Leading evangelical geneticist Dennis Venema and popular New Testament scholar Scot McKnight combine their expertise to offer informed guidance and answers to questions pertaining to evolution, genomic science, and the historical Adam. Some of the questions they explore include: - Is there credible evidence for evolution? - Do we descend from a population or are we the offspring of Adam and Eve? - Does taking the Bible seriously mean rejecting recent genomic science? - How do Genesis's creation stories reflect their ancient Near Eastern context, and how did Judaism understand the Adam and Eve of Genesis? - Doesn't Paul's use of Adam in the New Testament prove that Adam was a historical individual? The authors address up-to-date genomics data with expert commentary from both genetic and theological perspectives, showing that genome research and Scripture are not irreconcilable. Foreword by Tremper Longman III and afterword by Daniel Harrell.

Elements of Evolutionary Genetics

Author: Brian Charlesworth

Publisher: Roberts Publishers

ISBN: N.A

Category: Science

Page: 734

View: 6569

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Evolutionary genetics considers the causes of evolutionary change and the nature of variability in evolution. The methods of evolutionary genetics are critically important for the analysis and interpretation of the massive datasets on DNA sequence variation and evolution that are becoming available, as well for our understanding of evolution in general. This book shows readers how models of the genetic processes involved in evolution are made (including natural selection, migration, mutation, and genetic drift in finite populations), and how the models are used to interpret classical and molecular genetic data. The material is intended for advanced level undergraduate courses in genetics and evolutionary biology, graduate students in evolutionary biology and human genetics, and researchers in related fields who wish to learn evolutionary genetics. The topics covered include genetic variation, DNA sequence variability and its measurement, the different types of natural selection and their effects (e.g. the maintenance of variation, directional selection, and adaptation), the interactions between selection and mutation or migration, the description and analysis of variation at multiple sites in the genome, genetic drift, and the effects of spatial structure. The final two chapters demonstrate how the theory illuminates our understanding of the evolution of breeding systems, sex ratios and life histories, and some aspects of genome evolution.

Genome Chaos

Rethinking Genetics, Evolution, and Molecular Medicine

Author: Henry H. Heng

Publisher: Academic Press

ISBN: 9780128136355

Category: Medical

Page: 400

View: 8557

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Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

Genetics

Author: Hartl

Publisher: Jones & Bartlett Learning

ISBN: 1284156710

Category: Medical

Page: 830

View: 2666

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Genetics: Analysis of Genes and Genomes continues to treat transmission genetics, molecular genetics, and evolutionary genetics as fully integrated subjects and provides students with an unprecedented understanding of the basic process of gene transmission, mutation, expression, and regulation.

A Passion for DNA

Genes, Genomes, and Society

Author: James D. Watson

Publisher: OUP Oxford

ISBN: 9780198604280

Category: Science

Page: 250

View: 4247

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In 1953, two young and unknown scientists, James Watson and Francis Crick, sparked a worldwide revolution with their discovery of the molecular composition of DNA. In this collection of outspoken and topical essays, speeches and reports, Watson offers his unique insight into the advance of molecular genetics, the prospect of curing cancer over the next decade, how human genetic knowledge is likely to be used, particularly in relation to cloning and genetically modified food, as well as shedding light on his early life and career.

Ancestors in Our Genome

The New Science of Human Evolution

Author: Eugene E. Harris

Publisher: Oxford University Press, USA

ISBN: 0199978034

Category: Science

Page: 226

View: 3550

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In 2001, scientists were finally able to determine the full human genome sequence, and with the discovery began a genomic voyage back in time. Since then, we have sequenced the full genomes of a number of mankind's primate relatives at a remarkable rate. The genomes of the common chimpanzee (2005) and bonobo (2012), orangutan (2011), gorilla (2012), and macaque monkey (2007) have already been identified, and the determination of other primate genomes is well underway. Researchers are beginning to unravel our full genomic history, comparing it with closely related species to answer age-old questions about how and when we evolved. For the first time, we are finding our own ancestors in our genome and are thereby gleaning new information about our evolutionary past. In Ancestors in Our Genome, molecular anthropologist Eugene E. Harris presents us with a complete and up-to-date account of the evolution of the human genome and our species. Written from the perspective of population genetics, and in simple terms, the book traces human origins back to their source among our earliest human ancestors, and explains many of the most intriguing questions that genome scientists are currently working to answer. For example, what does the high level of discordance among the gene trees of humans and the African great apes tell us about our respective separations from our common ancestor? Was our separation from the apes fast or slow, and when and why did it occur? Where, when, and how did our modern species evolve? How do we search across genomes to find the genomic underpinnings of our large and complex brains and language abilities? How can we find the genomic bases for life at high altitudes, for lactose tolerance, resistance to disease, and for our different skin pigmentations? How and when did we interbreed with Neandertals and the recently discovered ancient Denisovans of Asia? Harris draws upon extensive experience researching primate evolution in order to deliver a lively and thorough history of human evolution. Ancestors in Our Genome is the most complete discussion of our current understanding of the human genome available.